Crank 2: High Voltage is the follow-up to Crank's electrifying success, keeping alive Hitman Chev Chelios (Jason Statham) as he launches himself on an electrifying chase through Los Angeles in pursuit of the Chinese mobster who has stolen his nearly indestructible heart.

The film opens with a sequence designed to look like a classic video game, depicting Chev Chelios fall from a helicopter during the final moments of the original Crank. Immediately after his fall, he is scooped off the street via snow shovel by group of Chinese medics and removed from the scene.